A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses
Lysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events.The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that are specific for K63-Ub hydrolysis.RAP80 targets the five-member nuclear BRCC36 complex to K63-Ub chains at